Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies
Identifieur interne : 003708 ( Main/Exploration ); précédent : 003707; suivant : 003709Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies
Auteurs : Seraphin Kuate [Allemagne] ; Jindrich Cinatl [Allemagne] ; Hans Wilhelm Doerr [Allemagne] ; Klaus Überla [Allemagne]Source :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Cellules Vero, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Humains, Lignée cellulaire, Modèles animaux, Modèles animaux de maladie humaine, Protéines de fusion recombinantes (génétique), Protéines de fusion recombinantes (immunologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Rappel de vaccin, Souris, Souris de lignée C57BL, Tests de neutralisation, Tumeurs (anatomopathologie), Tumeurs (immunologie), Vaccins antiviraux (immunologie), Vaccins synthétiques (immunologie), Virus du SRAS (immunologie), Vésicules de transport (immunologie).
- MESH :
- anatomopathologie : Tumeurs.
- génétique : Glycoprotéines membranaires, Protéines de fusion recombinantes, Protéines de l'enveloppe virale.
- immunologie : Glycoprotéines membranaires, Protéines de fusion recombinantes, Protéines de l'enveloppe virale, Tumeurs, Vaccins antiviraux, Vaccins synthétiques, Virus du SRAS, Vésicules de transport.
- sang : Anticorps antiviraux.
- Animaux, Cellules Vero, Glycoprotéine de spicule des coronavirus, Humains, Lignée cellulaire, Modèles animaux, Modèles animaux de maladie humaine, Rappel de vaccin, Souris, Souris de lignée C57BL, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Cell Line, Chlorocebus aethiops, Disease Models, Animal, Humans, Immunization, Secondary, Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Mice, Mice, Inbred C57BL, Models, Animal, Neoplasms (immunology), Neoplasms (pathology), Neutralization Tests, Recombinant Fusion Proteins (genetics), Recombinant Fusion Proteins (immunology), SARS Virus (immunology), Spike Glycoprotein, Coronavirus, Transport Vesicles (immunology), Vaccines, Synthetic (immunology), Vero Cells, Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Membrane Glycoproteins, Recombinant Fusion Proteins, Viral Envelope Proteins.
- chemical , immunology : Membrane Glycoproteins, Recombinant Fusion Proteins, Vaccines, Synthetic, Viral Envelope Proteins, Viral Vaccines.
- immunology : Neoplasms, SARS Virus, Transport Vesicles.
- pathology : Neoplasms.
- Animals, Cell Line, Chlorocebus aethiops, Disease Models, Animal, Humans, Immunization, Secondary, Mice, Mice, Inbred C57BL, Models, Animal, Neutralization Tests, Spike Glycoprotein, Coronavirus, Vero Cells.
Abstract
Infection with the SARS-associated coronavirus (SARS-CoV) induces an atypical pulmonary disease with a high lethality rate. Although the initial SARS epidemic was contained, sporadic outbreaks of the disease still occur, suggesting a continuous need for a vaccine against this virus. We therefore explored exosome-based vaccines containing the spike S proteins of SARS-CoV. S-containing exosomes were obtained by replacing the transmembrane and cytoplasmic domains of the S protein by those of VSV-G. The immunogenicity and efficacy of the S-containing exosomes were tested in mice and compared to an adenoviral vector vaccine expressing the S protein. Both, S-containing exosomes and the adenoviral vector vaccine induced neutralizing antibody titers. After priming with the SARS-S exosomal vaccine and boosting with the adenoviral vector the neutralizing antibody titers exceeded those observed in the convalescent serum of a SARS patient. Both approaches were effective in a SARS-S-expressing tumor challenge model and thus warrant further investigation.
Url:
DOI: 10.1016/j.virol.2006.12.011
PubMed: 17258782
PubMed Central: 7103344
Affiliations:
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Le document en format XML
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(genetics)</term><term>Recombinant Fusion Proteins (immunology)</term><term>SARS Virus (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>Transport Vesicles (immunology)</term><term>Vaccines, Synthetic (immunology)</term><term>Vero Cells</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Cellules Vero</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (génétique)</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux</term><term>Modèles animaux de maladie humaine</term><term>Protéines de fusion recombinantes (génétique)</term><term>Protéines de fusion recombinantes (immunologie)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Rappel de vaccin</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tests de neutralisation</term><term>Tumeurs (anatomopathologie)</term><term>Tumeurs (immunologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins synthétiques (immunologie)</term><term>Virus du SRAS (immunologie)</term><term>Vésicules de transport (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Recombinant Fusion Proteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term><term>Recombinant Fusion Proteins</term><term>Vaccines, Synthetic</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de fusion recombinantes</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de fusion recombinantes</term><term>Protéines de l'enveloppe virale</term><term>Tumeurs</term><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term><term>Virus du SRAS</term><term>Vésicules de transport</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Neoplasms</term><term>SARS Virus</term><term>Transport Vesicles</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunization, Secondary</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term><term>Neutralization Tests</term><term>Spike Glycoprotein, Coronavirus</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux</term><term>Modèles animaux de maladie humaine</term><term>Rappel de vaccin</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Infection with the SARS-associated coronavirus (SARS-CoV) induces an atypical pulmonary disease with a high lethality rate. Although the initial SARS epidemic was contained, sporadic outbreaks of the disease still occur, suggesting a continuous need for a vaccine against this virus. We therefore explored exosome-based vaccines containing the spike S proteins of SARS-CoV. S-containing exosomes were obtained by replacing the transmembrane and cytoplasmic domains of the S protein by those of VSV-G. The immunogenicity and efficacy of the S-containing exosomes were tested in mice and compared to an adenoviral vector vaccine expressing the S protein. Both, S-containing exosomes and the adenoviral vector vaccine induced neutralizing antibody titers. After priming with the SARS-S exosomal vaccine and boosting with the adenoviral vector the neutralizing antibody titers exceeded those observed in the convalescent serum of a SARS patient. Both approaches were effective in a SARS-S-expressing tumor challenge model and thus warrant further investigation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Admyre, C" uniqKey="Admyre C">C. Admyre</name></author><author><name sortKey="Grunewald, J" uniqKey="Grunewald J">J. Grunewald</name></author><author><name sortKey="Thyberg, J" uniqKey="Thyberg J">J. Thyberg</name></author><author><name sortKey="Gripenback, S" uniqKey="Gripenback S">S. Gripenback</name></author><author><name sortKey="Tornling, G" uniqKey="Tornling G">G. Tornling</name></author><author><name sortKey="Eklund, A" uniqKey="Eklund A">A. Eklund</name></author><author><name sortKey="Scheynius, A" uniqKey="Scheynius A">A. Scheynius</name></author><author><name sortKey="Gabrielsson, S" uniqKey="Gabrielsson S">S. Gabrielsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. 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Tenza</name></author><author><name sortKey="Ricciardi Castagnoli, P" uniqKey="Ricciardi Castagnoli P">P. Ricciardi-Castagnoli</name></author><author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name></author><author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Kuate, Seraphin" sort="Kuate, Seraphin" uniqKey="Kuate S" first="Seraphin" last="Kuate">Seraphin Kuate</name></noRegion><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><name sortKey="Uberla, Klaus" sort="Uberla, Klaus" uniqKey="Uberla K" first="Klaus" last="Überla">Klaus Überla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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